A PROCESS OF SULFOXIDATION OF BIOLOGICALLY ACTIVE COMPOUNDS

The present invention relates to a new process for the preparation of sulfoxides, preferably stereoselective preparation of substituted or unsubstituted chiral sulfinyl derivatives 2-(2-pyridylmethyl) sulfinyl-1H-benzimidazole by oxidation with oxaziridine in presence of suitable solvent and base, w...

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Main Authors RAJPUT MAHESH, RAMSING, MEHTA SATISH, RAMANLAL, GAWARI PRASHANT, SADASHIV, GURJAR MUKUND, KESHAV, GHARPURE MILIUND, MORESHWAR, MAHALE RAJENDRA, DAGESING, MAIKAP GOLAKCHANDRA, SUDARSHAN
Format Patent
LanguageEnglish
Russian
Published 30.03.2012
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to a new process for the preparation of sulfoxides, preferably stereoselective preparation of substituted or unsubstituted chiral sulfinyl derivatives 2-(2-pyridylmethyl) sulfinyl-1H-benzimidazole by oxidation with oxaziridine in presence of suitable solvent and base, wherein the solvent is not an ion solvent. Данное изобретение относится к новому способу получения сульфоксидов, предпочтительно стереоселективному получению замещенных или незамещенных хиральных сульфинильных производных 2-(2-пиридилметил)сульфинил-1H-бензимидазола окислением оксазиридином в присутствии подходящего растворителя и основания, при этом растворитель не является ионным растворителем.
Bibliography:Application Number: EA20100070021