A METHOD FOR THE PREPARATION OF SOLIFENACIN

A method of preparing (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-l-phenyl-2(1H)- isoquinoline carboxylate (solifenacin) or its pharmaceutically acceptable salts with high optic purity, wherein the crude solifenacin base is transformed to the hydrogen tartrate, which is then optionally transfo...

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Bibliographic Details
Main Authors JUNEK RICHARD, JIRMAN JOSEF
Format Patent
LanguageEnglish
Russian
Published 30.06.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A method of preparing (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-l-phenyl-2(1H)- isoquinoline carboxylate (solifenacin) or its pharmaceutically acceptable salts with high optic purity, wherein the crude solifenacin base is transformed to the hydrogen tartrate, which is then optionally transformed to another pharmaceutically acceptable salt or the base of solifenacin. A crystalline salt of solifenacin hydrogen tartrate. Способ получения (1S)-(3R)-1-азабицикло[2.2.2]окт-3-ил-3,4-дигидро-1-фенил-2(1Н)-изохинолинкарбоксилата (солифенацина) или его фармацевтически приемлемых солей с высокой степенью оптической чистоты, при котором неочищенное основание солифенацина переводят в гидротартрат, который затем, при необходимости, переводят в другую фармацевтически приемлемую соль или в основание солифенацина. Кристаллическая соль гидротартрат солифенацина.
Bibliography:Application Number: EA20090000744