POLYMORPHS OF CLOPIDOGREL HYDROCHLORIDE AND THEIR USE AS ANTITHROMBIC COMPOUNDS

The invention relates to crystalline forms I and II methyl-(S)-(+)-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2.c]pyridine-5-yl)-acetate hydrochloride of the Formula I and hydrates thereof, a process for the preparation thereof and pharmaceutical compositions containing the same. The new polymorphs...

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Main Authors FARKAS BELA, KORTVELYESSY GYULANE, NAGY KALMAN, BARKOCZY JOZSEF, SZENT KIRALLYI ZSUZSA, KOTAY NAGY PETER, GREGOR TAMAS, VERECZKEYNE DONATH GYORGYI, SIMIG GYULA
Format Patent
LanguageEnglish
Russian
Published 30.06.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to crystalline forms I and II methyl-(S)-(+)-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2.c]pyridine-5-yl)-acetate hydrochloride of the Formula I and hydrates thereof, a process for the preparation thereof and pharmaceutical compositions containing the same. The new polymorphs according to the invention exhibit blood platelet aggregation inhibiting and antithrombotic effect. Изобретение относится к кристаллическим формам I и II метил-(S)-(+)-(2-хлорфенил)-2-(6,7-дигидро-4Н-тиено[3,2с]пиридин-5-ил)ацетата гидрохлорида формулы (I) и его гидратов, к способу их получения и к фармацевтическим композициям, содержащим эти формы. Новые полиморфы согласно изобретению являются ингибиторами агрегации тромбоцитов крови и обладают антитромботическим эффектом.
Bibliography:Application Number: EA20040001025