CHEMICALLY-MODIFIED PROGENIPOIETIN CONJUGATES

The present invention provides a chemically modified Progenipoietins (ProGPs) prepared by binding a water soluble polymer to the protein. The chemically-modified protein according to the present invention may have a much longer lasting neutrophil-increasing activity than that of the un-modified ProG...

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Bibliographic Details
Main Authors HILLS, ROBERT, L, SIEGEL, NED, R, FINN, RORY, F
Format Patent
LanguageEnglish
Russian
Published 29.12.2005
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:The present invention provides a chemically modified Progenipoietins (ProGPs) prepared by binding a water soluble polymer to the protein. The chemically-modified protein according to the present invention may have a much longer lasting neutrophil-increasing activity than that of the un-modified ProGP, enabling reduced dose and scheduling opportunities. Настоящее изобретение относится к химически модифицированным прогенипоэтинам (ProGP), полученным путем связывания водорастворимого полимера с белком. Химически модифицированный белок по настоящему изобретению может обладать намного более продолжительной активностью по увеличению числа нейтрофилов по сравнению с таковой для немодифицированного ProGP, что обеспечивает снижение дозы и благоприятные возможности для режима введения.
Bibliography:Application Number: EA20040000070