N-HYDROXY-2-(ALKYL, ARYL OR HETEROARYL, SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS

• Main Authors: GROSU, GEORGE, THEODORE, O'DELL, MATHEW, JAMES, BAKER, JANNIE, LEA, DAVIS, JAMIE, MARIE, VENKATESAN, MUDUMBAI, ARANAPAKAM, COLE, DEREK, CECIL, HU, BAIHUA, JACOBSON, MARCY, PAMELA
• Format: Patent
• Language: English; Russian
• Published: 30.10.2003
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

1. A compound of the formula wherein: A is -S-, -SO- or SO2-; R is phenyl, naphthyl, heterocyclyl selected from the group: thienyl, triazolyl, pyridyl, pyrazinyl, imidazolyl, optionally benzocondensed and optionally substituted with C1-C6 alkyl, C1-C6 alkoxy or phenyl, aryloxy, benzyloxy and heteroaryloxy; or R is R -Y-Ph-Z where Y is O, S, NH or a simple bond, Z is A simple bond or C1-C4 alkylen; R is H, C1-C4 alkyl, acyl, benzyl, pyridylpropyl, 5-hydroxypentyl, 1-methylpyrolidinyl, tetrahydropyran-4-yl, chlorothienyl, 3-morpholine-4-ylpropyl, biphenyl, pyridyl, C3-C7 cycloalkyl; R is H, phenyl, carboxyphenyl, metoxycarbonylphenyl, benzyl, biphenylmethyl, C5-C10 alk(di)enyl and, C5-C10 alk(di)ynyl, cyclohexymethyl, heteroarylalkoxybenzyl, amino(C1-C6) alkyl, benzyloxymethyl, imidazolylmethyl, guanidinylbutyl; R is H, C1-C4 alkyl, C5-C10 alk(di)enyl and, C5-C10 alk(di)ynyl, phenyl (C1-C4) alkyl, phenoxybutyl, hydroxyaminocarbonyl (C1-C4) alkyl; or R and R , taken together with the carbon atom to which they are attached, form a piperidine ring which is optionally substituted with N-group selected from phenyl-C1-C4 alkyl, which may be substituted by C1-C6 alkoxy, biphenyl- C1-C6 alkyl, C2-C10 alkenyl, C1-C8 alkyl, C4-C10 cycloalkyl or phenoxy- C1-C6 alkyl; R is H, provided that a). when A is S, R is H and R is H, then R is not thienyl, optionally mono or disubstituted C1-C6 alkyl or C1-C6 alkoxy, b). when A is SO2, R is H and R is 4-phenyl-n-butyl, then R is not 3,4-dimethoxyphenyl, and provided that compounds are excluded, when: a. A is S, R and R are H and R is phenyl comprising three carbon atoms and two bromine atoms as a ring substituents; b. A is S, R and R are H and R is phenyl comprising three carbon atoms, one chlorine atom and one bromine atom as a ring substituents; c. A is S, R and R are H and R is phenyl comprising two carbon atoms and three bromine atoms as a ring substituents d. A is S, R and R are H and R is phenyl comprising two carbon atoms and three chlorine atoms as a ring substituents. 2. The compound according to claim 1, wherein: R is phenyl, naphthyl, heterocyclyl such as pyridyl, thienyl or imidazolyl, optionally substituted with C1-C6 alkyl, C1-C6 alkoxy, C6-C10 aryloxy or heteroaryloxy; R is C5-C10 alk(di)enyl and, C5-C10 alk(di)ynyl; R is C1-C4 alkyl, C5-C10 alk(di)enyl and, C5-C10 alk(di)ynyl, phenyl (C1-C4) alkyl or phenoxybutyl; or a pharmaceutically acceptable salt thereof. 3. A compound according to claim 1 selected from the group of compounds comprising of: 2-(4-methoxy-benzenesulfonyl)-2,5-dimethyl-hex-4-enoic acid hydroxyamide; 3-(biphenyl-4-yl)-N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-propionamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-propionamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-pyridin-3-yl-propionamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-quinolin-6-yl-propionamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[4-(2-morpholin-1-yl-ethoxy)-phenyl]-propionamide; 2-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-methoxy-benzenesulfonyl)-propionic acid hydroxyamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[4-(N,N-diethyl amino-ethoxy)-phenyl]-propionamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[3-(2-piperidin-1-yl-ethoxy)-phenyl]-propionamide N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[3-(2-morpholin-1-yl-ethoxy)-phenyl]-propionamide; N-hydroxy-2-(4-ethoxy-benzenesulfonyl)-2-methyl-3-[4-(N,N-diethyl amino-ethoxy)-phenyl]-propionamide; N-hydroxy-2-(4-n-butoxy-benzenesulfonyl)-2-methyl-3-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-propionamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[3-(N,N-diethyl amino-ethoxy)-phenyl]-propionamide; 2-(4-methoxy-benzenesulfonyl)-5-methyl-2-(3-methyl-but-2-enyl)-hex-4-enoic acid hydroxyamide; 2R*-(4-methoxy-phenyl-S*-sulfinyl)-heptanoic acid hydroxyamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[4-(N,N-diisopropyl amino-ethoxy)-phenyl]-propionamide; or a pharmaceutically acceptable salt thereof. 4. A compound according to claim 1 selected from the group of compounds comprising of: N-hydroxy-2-(4-methoxy-phenylsulfanyl)-2-methyl-3-phenyl-propionamide, N-hydroxy-2-(4-methoxy-phenylsulfanyl)-2-phenyl-acetamide, 2-(4-methoxy-phenylsulfanyl)-2,5-dimethyl-hex-4-enoic acid hydroxyamide, N-hydroxy-2-(4-methoxy-phenylsulfanyl)-3-methyl-butyramide, N-hydroxy-2-(4-methoxy-benzenesulfinyl)-2-methyl-3-phenyl-propionamide, 2-(4-methoxy-benzenesulfinyl)-2,5-dimethyl-hex-4-enoic acid hydroxyamide, N-hydroxy-2-(4-methoxy-benzenesulfinyl)-3-methyl-butyramide, N-hydroxy-2-(4-methoxy-benzenesulfinyl)-2-phenyl-acetamide, N-hydroxy-2-(4-methoxy-benzenesulfonyl)-3-phenyl-propionamide, 2-(4-methoxy-benzenesulfonyl)-hexanoic acid hydroxyamide, 2-(4-methoxy-benzene sulfonyl)-tetradecanoic hydroxyamide, N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-phenyl-propionamide, 2-(4-methoxy-benzenesulfonyl)-2,5-dimethyl-hex-4-enoic acid hydroxyamide, 2-(4-methoxy-benzenesulfonyl)-2,5,9-trimethyl-deca-4,8-dienoic acid hydroxyamide; 3-cyclohexyl-N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-propionamide, 2-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-methoxy-benzenesulfonyl)-pentanoic acid hydroxyamide; 3-(4-(3-[4-(3-chloro-phenyl)-piperazin-1-yl]-propoxy}-phenyl)-N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-propionamide; 2-(4-methoxy-benzenesulfonyl)-5-methyl-2-[4-(2-morpholin-4-yl-ethoxy)-benzyl]-hex-4-enoic acid hydroxyamide; (4E)-2-(4-methoxy-benzenesulfonyl)-5,9-dimethyl-2-[4-(2-morpholin-4-yl-ethoxy)-benzyl]-deca-4,8-dienoic acid hydroxyamide; 2-[4-(2-diethylamino-ethoxy)-benzyl]-2-(4-methoxy-benzenesulfonyl)-hexanoic acid hydroxyamide; 2-[4-(2-diethylamino-ethoxy)-benzyl]-2-(4-methoxy-benzenesulfonyl)-hexanoic acid hydroxyamide; N-hydroxy-2-(4-n-butoxy-benzenesulfonyl)-2-methyl-3-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-propionamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[3-(2-N,N-diethyl aminoethoxy)-phenyl]-propionamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[3-(2-morpholin-1-yl-ethoxy)-phenyl]-propionamide; 6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-methoxy-benzenesulfonyl)-2-methyl-hexanoic acid hydroxyamide; 3-[4-(2-diethylamino-ethoxy)-phenyl]-2-(4-furan-2-yl-benzenesulfonyl)-N-hydroxy-2-methyl-propionamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-[4-(2-morpholin-4-yl-ethoxy)-benzyl]-butyramide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-butyramide; 2-(4-methoxy-benzenesulfonyl)-2-[4-(2-morpholin-4-yl-ethoxy)-benzyl]-pentanoic acid hydroxyamide; 2-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-methoxy-benzenesulfonyl)-octanoic acid hydroxyamide; 2-(4-methoxy-benzenesulfanyl)-octanoic acid hydroxyamide; 2-(4-fluoro-phenylsulfanyl)-octanoic acid hydroxyamide; 2-(1-methyl-1H-imidazol-2-ylsulfanyl)-octanoic acid hydroxyamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-3-naphthalen-2-yl-propionamide' N-hydroxy-2-(4-methoxy-phenylmethanesulfonyl)-2-methyl-3-phenyl propionic acid hydroxamide; 5-methyl-2-(3-methyl-but-2-enyl)-2-(toluene-4-sulfonyl)-hex-4-enoic acid hydroxyamide; 2-methyl-2-(2-methyl-furan-3-sulfonyl)-3-phenyl-propionic acid hydroxamide; 2-methyl-2-(2-methyl-furan-3-sulfonyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-propionic acid hydroxamide; 2-methyl-3-[4-(2-piperidin-1-yl-ethoxy)-phenyl-2-(thiophene-2-sulfonyl)-propionic acid hydroxamide; 2-(octane-1-sulfonyl)-3-[4-(2-piperidin-yl-ethoxy)-phenyl]propionic acid hydroxamide; 2-methyl-3-phenyl-2-(thiophene-2-sulfonyl)-propionic acid hydroxamide; 2-[8-(1-carboxy-ethanesulfonyl)-octane-1-sulfonyl]-propionic acid hydroxyamide; 2-(4-bromo-benzenesulfonyl)-2-methyl-3-[4-(2-piperidine-1-yl-ethoxy)-phenyl]-propionic acid hydroxamide; 3-(4-bromo-phenyl)-N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-propionamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-naphthalen-2-yl-propionamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-3-methyl-butyramide; 1-(4-methoxy-benzenesulfonyl)-cyclopentanecarboxylic acid hydroxyamide; 3-(2-bromo-phenyl)-N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-propionamide; 2-(4-methoxy-benzenesulfonyl)-2-methyl-5-phenyl-pent-4-enoic acid hydroxyamide; 2-(4-methoxy-benzenesulfonyl)-5-phenyl-2-(3-phenyl-propyl)-pentanoic acid hydroxyamide; 2-allyl-2-(4-methoxy-benzenesulfonyl)-pent-4-enoic acid hydroxyamide; 2-(4-methoxy-benzenesulfonyl)-2-propyl-pentanoic acid hydroxyamide; 2-benzyl-N-hydroxy-2-(4-methoxy-benzenesulfonyl)-3-phenyl-propionamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-pyridin-3-yl-propionamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-naphthalen-2-yl-propionamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-3-methyl-butyramide; 1-(4-methoxy-benzenesulfonyl)-cyclopentanecarboxylic acid hydroxyamide; 3-(2-bromo-phenyl)-N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-propionamide; 2-(4-methoxy-benzenesulfonyl)-2-methyl-5-phenyl-pent-4-enoic acid hydroxyamide; 2-(4-methoxy-benzenesulfonyl)-5-phenyl-2-(3-phenyl-propyl)-pentanoic acid hydroxyamide; 2-allyl-2-(4-methoxy-benzenesulfonyl)-pent-4-enoic acid hydroxyamide; 2-(4-methoxy-benzenesulfonyl)-2-propyl-pentanoic acid hydroxyamide; 2-benzyl-N-hydroxy-2-(4-methoxy-benzenesulfonyl)-3-phenyl-propionamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-pyridin-3-yl-propionamide; 2-(4-methoxy-benzenesulfonyl)-2-pyridin-3-ylmethyl-decanoic acid hydroxyamide; 2-(4-methoxy-benzenesulfonyl)-5-methyl-2-pyridin-3-ylmethyl-hex-4-enoic acid hydroxyamide; 2-benzyl-4-diisopropylamino-N-hydroxy-2-(4-methoxy-benzenesulfonyl)-butyramide; 3-cyclohexyl-N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-pyridin-3-ylmethyl-propionamide; 2-(4-methoxy-benzenesulfonyl)-4-methyl-2-pyridin-3-ylmethyl-pentanoic acid hydroxyamide; N-hydroxy-2-(4-methoxy-benzenesulfonyl)-2-methyl-3-quinolin-6-yl-propionamide; 2-(4-methoxy-benzenesulfonyl)-6-phenoxy-2-pyridin-3-ylme Матричные металлопротеиназы (ММП) представляют собой группу ферментов, вовлеченных в пато