COMPUESTOS ÚTILES EN TERAPIA

• Main Authors: KEVIN NEIL DACK, PAUL ANTONY BRADLEY, SARAH ELIZABETH SKERRATT, PATRICK STEPHEN JOHNSON
• Format: Patent
• Language: Spanish
• Published: 30.06.2007
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Los compuestos de fórmula (I), o uno de sus derivados farmacéuticamente aceptables, en donde R1 y R3 representan, de modo independiente, H, alquilo C1-6, cicloalquilo C3-8 o halógeno; R2 representa alquilo C1-6, CF3 o arilo; a representa 1 ó 2; R4, R5, R7 y R8 representan, de modo independiente, H, alquilo C1-6, alquil C1-6oxi, CN o halógeno, o R4 y R5, o R7 y R8, junto con el anillo al que están unidos, forman un arilo o sistema de anillos heterocíclicos fusionados; m representa C o N; Y representa CH2 u O; R6 representa H, CN o halo, pero cuando X representa N, entonces R6 no está presente; pueden ser de utilidad para tratar endometriosis, fibroides uterinos (leiomiomas), menorragia, adenomiosis, dismenorrea primaria y secundaria (incluyendo los síntomas de dispareunia, disquexia y dolor pélvico crónico), o síndrome de dolor pélvico crónico. Compounds of formula (I), or a pharmaceutically acceptable derivative thereof, wherein R1 and R3 independently represent H, C1-6alkyl, C3-8cycloalkyl, or halogen; R2 represents C1-6alkyl, CF3 or aryl; a represents 1 or 2; R4, R5, R7 and R8 independently represent H, C1-6alkyl, C1-6alkyloxy, CN or halogen, or R4 and R5, or R7 and R8, together with the ring to which they are attached form an aryl or heterocyclic fused ring system; X represents C or N; Y represents CH2 or O; R6 represents H, CN or halo provided that, when X represents N, R6 is absent. The compounds are useful for treating endometriosis, uterine fibroids (leiomyomata), menorrhagia, adenomyosis, primary and secondary dysmenorrhoea (including symptoms of dyspareunia, dyschexia and chronic pelvic pain), or chronic pelvic pain syndrome.