FREMGANGSMÅDE TIL FREMSTILLING AF [(5-(3-CHLORPHENYL)-3-HYDROXYPYRIDIN-2-CARBONYL)-AMINO]EDDIKESYRE FRA 5-((3-CHLORPHENYL)-3-CHLOR-PYRIDIN-2-YL)-NITRIL OG FREMGANGSMÅDE TIL FREMSTILLING AF 5-((HALOGENPHENYL)-3-HALOGEN-PYRIDIN-2-YL)-NITRILDERIVATER

The present invention relates to a process for preparing N-[[5-(3- chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-glycine (compound (5)), from the intermediates 5-(3-chlorophenyl)-3-chloro-2- pyridinecarbonitrile (compound (1)), 5-(3-chlorophenyl)-3-methoxy-2- pyridinecarbonitrile (compound (2)), 5-(...

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Bibliographic Details
Main Authors JANUSZ, John, Michael, DIXON, Craig, Edward, COPP, James, Densmore, OUDENES, Jan, LANTHIER, Christopher, M, GORIN, Boris, LU, Alan, Qingbo
Format Patent
LanguageDanish
Published 06.12.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a process for preparing N-[[5-(3- chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-glycine (compound (5)), from the intermediates 5-(3-chlorophenyl)-3-chloro-2- pyridinecarbonitrile (compound (1)), 5-(3-chlorophenyl)-3-methoxy-2- pyridinecarbonitrile (compound (2)), 5-(3-chlorophenyl)-3-hydroxy-2- pyridinecarboxylic acid (compound (3)). Compound (5) is an intermediate in the preparation of prolyl hydroxylase inhibitors.
Bibliography:Application Number: DK20210004405T