FREMGANGSMAADE TIL STRUKTURFRANSFORMATION AF RHOMBOEDRISK KRYSTALLISERET INSULIN SAMT FORHALET VIRKENDE KRYSTALSUSPENSION AF INSULIN FREMSTILLET VED FREMGANGSMAADEN
1. A process for the structural transformation of rhombohedrally crystallized insulin, preferably of pig origin, having a 4-Zn structure to rhombohedrons having a 2-Zn structure, which comprises maintaining the crystals having a 4-Zn structure in an aqueous medium containing less than 6% of sodium c...
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Main Author | |
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Format | Patent |
Language | Danish |
Published |
23.02.1981
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Edition | 3 |
Subjects | |
Online Access | Get full text |
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Summary: | 1. A process for the structural transformation of rhombohedrally crystallized insulin, preferably of pig origin, having a 4-Zn structure to rhombohedrons having a 2-Zn structure, which comprises maintaining the crystals having a 4-Zn structure in an aqueous medium containing less than 6% of sodium chloride, the pH of which medium is adjusted to 4.5 to 6.0 and maintained stable by addition of a buffer, at a temperature ranging from room temperature to 45 degrees C until in a sample crystals of the 4-Zn structure are no longer present. |
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Bibliography: | Application Number: DK19800003593 |