FREMSTILLING AF LATANOPROSTENBUNOD AF ØNSKET, FORUDDEFINERET KVALITET VED HJÆLP AF GRAVITATIONSKROMATOGRAFI

The subject of the invention is a process for the preparation of Latanoprostene bunod of formula (I) with a purity higher than 95% where chromatography is used applying normal phase gravity silica gel column chromatography where the used silica gel is irregular silica gel or spherical silica gel an...

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Bibliographic Details
Main Authors LÁSZLÓFI, István, TAKÁCS, László, KARDOS, Zsuzsanna, Buzder-Lantos, Péter, HAVASI, Gábor, FEKETE, Ibolya, HORTOBÁGYI, Irén
Format Patent
LanguageDanish
Published 16.10.2023
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The subject of the invention is a process for the preparation of Latanoprostene bunod of formula (I) with a purity higher than 95% where chromatography is used applying normal phase gravity silica gel column chromatography where the used silica gel is irregular silica gel or spherical silica gel an as eluent and eluent mixture consisting of an apolar and a polar solvent is used and if desired, contamination of the purified compound of formula I arising from the solvents are removed by silica gel filtration chromatography.
Bibliography:Application Number: DK20160822513T