N-(5-((Aryl eller heteroaryl)methyloxy)pentyl)-substituerede iminosukre som inhibitorer af glucosylceramidsyntase
The present invention concerns D-deoxygalactonojirimycin derivatives shown below. These compounds display an increased inhibitory potency towards GCS, and/or an increased inhibitory potency towards GBA2, and/or a decreased inhibitory potency towards GBA1, relative to known deoxynojirimycin derivativ...
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Main Authors | , , , , |
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Format | Patent |
Language | Danish |
Published |
08.10.2018
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention concerns D-deoxygalactonojirimycin derivatives shown below. These compounds display an increased inhibitory potency towards GCS, and/or an increased inhibitory potency towards GBA2, and/or a decreased inhibitory potency towards GBA1, relative to known deoxynojirimycin derivatives of the same D -galacto configuration. Therefore, compounds of the present invention are effective in the treatment of diseases which are associated with an irregular level of cytosolic or lysosomal glucosylceramide and/or higher glycosphingolipids, such as a lysosomal storage disorder, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Sandhoff disease, GM1 gangliosidosis, Sialidosis, Niemann Pick disease type C and AMRF, or a symptom of one of the diseases collectively classed as metabolic syndrome, such as obesity, insulin resistance, hyperlipidemia, hypercholesterolemia, polycystic kidney disease, type II diabetes and chronic inflammation, or a neurodenegerative disorder, such as Parkinson disease or Lewy-body dementia. |
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Bibliography: | Application Number: DK20150719845T |