3-ARYL-5-SUBSTITUERET-ISOQUINOLIN-1-ON-FORBINDELSER OG TERAPEUTISK ANVENDELSE DERAF

• Main Authors: BOFFEY, Raymond, John, JARVIS, Ashley, Nicholas, PERRIOR, Trevor, Robert, PORTER, Roderick, Alan, ELLIOTT, Richard, James, Rowland, ASHWORTH, Alan, LORD, Christopher, James, KEY, Rebekah, Elisabeth, NICULESCU-DUVAZ, Dan, BAYFORD, Melanie, Jayne, AQIL, Rehan, SKONE, Philip, Alan, HOPKINS, Anna, FIRTH-CLARK, Stuart
• Format: Patent
• Language: Danish
• Published: 23.04.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 3-aryl-5-substituted-2/-/-isoquinolin-1-one compounds that, inter alia, inhibit PARP (e.g., PARP1, TNKS1, TNKS2, etc.) and/or Wnt signalling. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit PARP (e.g., PARP1, TNKS1, TNKS2, etc.); to inhibit Wnt signalling; to treat disorders that are ameliorated by the inhibition of PARP (e.g., PARP1, TNKS1, TNKS2, etc.); to treat disorders that are ameliorated by the inhibition of Wnt signalling; to treat proliferative conditions such as cancer, etc.