Nyt benzazepinderivat og farmaceutisk anvendelse deraf

• Main Authors: KUNO, Yuka, KURUMAZUKA, Daisuke, OKABE, Morio, KATAOKA, Hiroyo, MIYAZAWA, Toshiyuki, NAGANO, Hiroki, TAKAHASHI, Naoki, TAKEUCHI, Mitsuaki, KASUGAI, Nobuyoshi, FUJIEDA, Hiroki, SAKAI, Keita, GOTOH, Izumi, ASANO, Yukiyasu, YAMADA, Yurie, HARADA, Satoko, IZUCHI, Toru, KITAMOTO, Katsunori, OHSAWA, Yasushi
• Format: Patent
• Language: Danish
• Published: 07.08.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

An object of the present invention is to provide a compound having a V2 receptor agonistic activity. Provided is a pharmaceutical composition which contains, as an active ingredient, a compound represented by the general formula (I) described below: [wherein R 1 is the formula described below: (wherein A is a lower alkylene group which may be substituted with a lower alkyl group, or the like; R 6 is a hydrogen atom, or the like; R 7 is a hydroxyl group, an aromatic heterocyclic group which may be substituted with a lower alkyl group, a carbamoyl group, or the like) ; R 2 is a hydrogen atom or a lower alkyl group; R 3 is a lower alkyl group which may be substituted with 1 to 3 fluorine atoms, or a halogen atom; R 4 is a five-membered aromatic monocyclic heterocyclic group, a five-membered non-aromatic monocyclic heterocyclic group, or the like, (provided that each of these heterocyclic groups contains at least one nitrogen atom and may be substituted with a lower alkyl group) ; and R 5 is a lower alkyl group, a halogen atom, or the like], or a pharmacologically acceptable salt thereof.