AMID-SUBSTITUEREDE HETEROCYKLISKE FORBINDELSER, DER ER ANVENDELIGE SOM MODULATORER AF IL-12, IL-23 OG/ELLER IFN-ALPHA

Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition.

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Bibliographic Details
Main Authors ZHANG, Yanlei, TOKARSKI, John S, BATT, Douglas G, KUMAR, Amit, LIN, Shuqun, WROBLESKI, Stephen T, SPERGEL, Steven H, MOSLIN, Ryan M, LIU, Chunjian, WEINSTEIN, David S
Format Patent
LanguageDanish
Published 21.01.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition.
Bibliography:Application Number: DK20130811640T