SUBSTITUEREDE BENZOPHENONER OG SALTE DERAF SAMT DERES FREMSTILLING OG ANVENDELSE

Substituted benzophenones of the formula (I) in which Ph represents unsubstituted or substituted phenyl and R represents free, esterified or amidated carboxy, have anti-inflammatory and/or analgesic properties and can be used as active ingredients in medicaments. They are manufactured, for example,...

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Bibliographic Details
Main Authors FERRINI PIER GIORGIO, SPRECHER ANDREAS VON, HAAS GEORGES
Format Patent
LanguageDanish
Published 16.12.1984
Edition4
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Substituted benzophenones of the formula (I) in which Ph represents unsubstituted or substituted phenyl and R represents free, esterified or amidated carboxy, have anti-inflammatory and/or analgesic properties and can be used as active ingredients in medicaments. They are manufactured, for example, as follows: a compound or a mixture of compounds of the formula (II) in which X1 and X2 together represent a group of the formula -C(=O)-O that is bonded via the carbonyl group to the radical Ph and X3 represents hydrogen, or one of the radicals X1 and X3 represents a group of the formula -C(=O)-Z, the other represents hydrogen and X2 represents a group R'O- in which R' represents hydrogen or a hydroxy-protecting group, is subjected to acid treatment and the primary product is decomposed solvolytically.
Bibliography:Application Number: DK19840002917