GLUCOSYLCERAMIDSYNTHASE-INHIBITORER

The invention relates to inhibitors of glucosylceramide synthase (GCS) of formula (I) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

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Bibliographic Details
Main Authors BESKROVNAYA, Oxana, CELATKA, Cassandra, LEONARD, John, SKERLJ, Renato, BOURQUE, Elyse, MAKINO, Elina, METZ, Markus, Xiang, Yibin, NATOLI, Thomas, GOOD, Andrew, CABRERA-SALAZAR, Mario, A, HIRTH, Bradford, CHENG, Seng, H, SCHEULE, Ronald, K, HUSSON, Herve, MARSHALL, John, ZHAO, Zhong, JANCSICS, Katherine
Format Patent
LanguageDanish
Published 09.05.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to inhibitors of glucosylceramide synthase (GCS) of formula (I) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
Bibliography:Application Number: DK20130765893T