PYRROLIDINYLUREA-, PYRROLIDINYLTHIOUREA- OG PYRROLIDINYLGUANIDINFORBINDELSER SOM TRKA-KINASEINHIBITORER

or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Y, B, and Ring C are as defined herein, and wherein the Y-B moiety and the NH-C(═X)-NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are use...

Full description

Saved in:
Bibliographic Details
Main Authors ALLEN, Shelley, KERCHER, Timothy, ANDREWS, Steven, W, SEO, Jeongbeob, CONDROSKI, Kevin, R, HAAS, Julia, HUANG, Lily, KOLAKOWSKI, Gabrielle R, BLAKE, James, F, JIANG, Yutong
Format Patent
LanguageDanish
Published 06.02.2017
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Y, B, and Ring C are as defined herein, and wherein the Y-B moiety and the NH-C(═X)-NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
Bibliography:Application Number: DK20120743553T