MAKROCYKLISKE FORBINDELSER SOM PROTEINKINASEHÆMMERE

There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or...

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Main Authors BLANCO APARICIO, Carmen, PASTOR FERNÁNDEZ, Joaquín, RODRÍGUEZ HERGUETA, Antonio, ÁLVAREZ ESCOBAR, Rosa María, MARTÍN HERNANDO, Jose Ignacio, RIESCO FAGUNDO, Rosario Concepción, CEBRIÁN MUÑOZ, David Álvaro, GARCÍA GARCÍA, Ana Belén
Format Patent
LanguageDanish
Published 21.03.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.
Bibliography:Application Number: DK20120754044T