ANVENDELSE AF ANTI-CGRP- ELLER ANTI-CGRP-R-ANTISTOFFER ELLER ANTISTOFFRAGMENTER TIL BEHANDLING ELLER FOREBYGGELSE AF KRONISKE OG AKUTTE FORMER FOR DIARRÉ

The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically effective amount of antibodies and fragments thereof having binding specificity for CGRP. In particular the methods prevent or reduce diarrh...

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Bibliographic Details
Main Authors LATHAM, John A, RUSSO, Andrew F, RADDANT, Ann C, RECOBER, Ana, KAISER, Eric A, KOVACEVICH, Brian Robert, KUBURAS, Adisa, SMITH, Jeffrey T.L, GARCIA-MARTINEZ, Leon F
Format Patent
LanguageDanish
Published 04.11.2019
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically effective amount of antibodies and fragments thereof having binding specificity for CGRP. In particular the methods prevent or reduce diarrhea in conditions or treatments resulting in elevated CGRP levels, e.g., in the GI tract (colon) that are associated with diarrhea and/or improper electrolyte and fluid excretion from the bowel or urinary system. More specifically, this invention relates to treatments using the anti-CGRP antibodies and fragments described herein, and binding fragments thereof.
Bibliography:Application Number: DK20120788717T