FARMACEUTISK PRODUKT TIL INTRAORAL LEVERING AF NIKOTIN OMFATTENDE TROMETAMOL SOM BUFFERMIDDEL

• Main Authors: STEEN, Per, NICKLASSON, Fredrik, LINDELL, Katarina, THYRESSON, Kristina, WALTERMO, Åsa, SCHLÜTER, Anette, BOSSON, Bengt, OLSSON, Roland, MODY, Seema, K, Pålsson, Magnus, DYMITROWICS, Darek, HUGERTH, Andreas
• Format: Patent
• Language: Danish
• Published: 04.12.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A pharmaceutical oral formulation for delivering nicotine in any form to a subject by transmucosal uptake in the oral cavity comprising nicotine in any form, wherein said oral formulation is buffered with at least trometamol. Also contemplated is a method for the oral delivery of nicotine in any form, a method for the reduction of the urge to smoke or use tobacco as well as methods for manufacturing the oral formulation, the use of the oral formulation for obtaining transmucosal uptake of nicotine in the oral cavity of a subject, and use of nicotine for the production of an oral formulation for the treatment of a disease selected from the group consisting of tobacco or nicotine dependence, Alzheimer's disease, Crohn's disease, Parkinson's disease, Tourette's syndrome, ulcerous colitis and post-smoking-cessation weight control.