Anti-CD19-Antistoffer med reduceret immunogenicitet
Pharmaceutical compositions comprising specific anti-CD19 B4 antibodies with modified variable regions in combination with chemotherapeutic agents are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regio...
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Main Authors | , , |
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Format | Patent |
Language | Danish |
Published |
18.07.2011
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Subjects | |
Online Access | Get full text |
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Summary: | Pharmaceutical compositions comprising specific anti-CD19 B4 antibodies with modified variable regions in combination with chemotherapeutic agents are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response. Moreover the specific anti-CD19 antibodies are expressed in good yields in YB2/0 cells and elicit improved ADCC. |
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Bibliography: | Application Number: DK20060829801T |