Peptider og derivater af APL-TYPE af HSP60 og famaceutiske sammensætninger

Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of...

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Main Authors LORENZO PEREZ, NORAILYS, MORERA CORDOVA, VIVIAN, PADRON PALOMARES, GABRIEL R, DOMINGUEZ HORTA, MARIA DEL CARMEN, LOPEZ MARIN, NELIA, COSME DIAZ, CARELIA, MERINO GARCIA, NELSON J, BARBERA BETANCOURT, ARIANA, HERNANDEZ GARCIA, VAZQUEZ BONACHEA, SUAREZ ALBA, JOSE
Format Patent
LanguageDanish
Published 29.05.2012
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.
Bibliography:Application Number: DK20050794474T