Fremgangsmåde til fremstilling af quinolincarboxylsyrederivater samt mellemprodukt, der kan anvendes ved fremgangsmåden

• Main Authors: BALOGH, MARIA, VASVARI, LELLE, KERESZTURI, GEZA, RITLI, PETER, PAJOR, ANIKO, MARMAROSI, KATALIN, HORVATH, AGNES, HERMECZ, ISTVAN, SIPOS, JUDIT
• Format: Patent
• Language: Danish
• Published: 10.05.2004
• Edition: 7
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a new process for the preparation of compounds of the general Formula I (* CHEMICAL STRUCTURE *) (I) wherein R stands for piperazinyl, 4-methyl-piperazinyl or 4-ethyl-piperazinyl group and pharmaceutically acceptable salts thereof which comprises reacting a compound of the general Formula II (* CHEMICAL STRUCTURE *) (II) wherein R1 and R2 stand for halogen, for an aliphatic acyloxy group containing 2 to 6 carbon atoms and optionally substituted by halogen, or for an aromatic acyloxy group containing 7 to 11 carbon atoms with a piperazine derivative of the general Formula III (* CHEMICAL STRUCTURE *) (III) wherein R3 stands for hydrogen, methyl or ethyl or a salt thereof and subjecting the compound of the general Formula IV (* CHEMICAL STRUCTURE *) (IV) thus obtained wherein R, R1 and R2 are as stated above to hydrolysis after or without isolation and if desired converting the compound of the general Formula I thus obtained into a salt thereof or setting free the same from its salt. The compounds of the general Formula I are known antibacterial agents.