alfa-Methyl-6-(2-quinolinylmethoxy)-2-naphthaleneddikesyre-aminsalte, farmaceutiske præparater af disse samt deres anvendelse til fremstilling af farmaceutiske produkter med lipoxygenaseaktivitet og leukotrien-antagonistaktivitet og cellebeskyttende aktivitet

The invention concerns alpha -methyl-6-(2-quinolinylmethoxy)-2-naphthalene acetic acid, amine salts wherein the amine is an hydroxyalkylamine of formula NR1R2R3 wherein R1 is hydrogen, phenyl, alkyl of 1-6 carbon atoms or hydroxyalkyl of 1-6 carbon atoms, R2 is hydrogen, alkyl of 1-6 carbon atoms or...

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Bibliographic Details
Main Authors BICKSLER, JAMES JACOB, MUSSER, JOHN HENRY, KUBRAK, DENNIS MARTIN, KREFT III, ANTHONY FRANK, GIBERSON, JOHN WILLIAM
Format Patent
LanguageDanish
Published 28.11.1994
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention concerns alpha -methyl-6-(2-quinolinylmethoxy)-2-naphthalene acetic acid, amine salts wherein the amine is an hydroxyalkylamine of formula NR1R2R3 wherein R1 is hydrogen, phenyl, alkyl of 1-6 carbon atoms or hydroxyalkyl of 1-6 carbon atoms, R2 is hydrogen, alkyl of 1-6 carbon atoms or hydroxyalkyl of 1-6 carbon atoms and R3 is hydroxyalkyl of 1-12 carbon atoms. The preferred salts are the tromethamine salts. The amine salts have enhanced activity as compared to the parent acids.
Bibliography:Application Number: DK19900001175