GONADOLIBERINDERIVATER OG DERES FARMACEUTISK ACCEPTABLE SYREADDITIONSSALTE ELLER METALCOMPLEXER, EN FREMGANGSMAADE TIL FREMSTILLING HERAF SAMT ET FARMACEUTISK PRAEPARAT INDEHOLDENDE DISSE

The invention relates to gonadoliberin derivatives of the general formula (I) Glp-His-Trp-Ser-Tyr-X1-X2-X3-Pro-X4 wherein X1 is a glycyl group or a D-isomer of any natural or synthetic amino acid group, X2 represents an L-amino acid group having 1 to 4 carbon atoms in the side chain, L-phenyl-alanyl...

Full description

Saved in:
Bibliographic Details
Main Authors KERI, GYOERGY, TEPLAN, ISTVAN, HORVATH, ANIKO, NIKOLICS, KAROLY, SZOEKE, BALAZS, GULYAS, TAMAS
Format Patent
LanguageDanish
Published 31.08.1992
Edition5
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The invention relates to gonadoliberin derivatives of the general formula (I) Glp-His-Trp-Ser-Tyr-X1-X2-X3-Pro-X4 wherein X1 is a glycyl group or a D-isomer of any natural or synthetic amino acid group, X2 represents an L-amino acid group having 1 to 4 carbon atoms in the side chain, L-phenyl-alanyl or L-tryptophyl group, X3 represents an L-amino acid group having a C1-4 alkyl or C2-4 alkanoyl-amide side chain, and X4 is a glycine amide or a C1-4 alkyl amide group, with the proviso that if X1 stands for a group other than glycyl and X2 is a tryptophyl group then X3 may not be leucyl, and the addition salts formed with therapeutically useable acids and complexes thereof. Furthermore the invention relates to a process for preparing these compounds. The new gonadoliberin derivatives can be effectively used for the reproduction process of fish, birds and mammals.
Bibliography:Application Number: DK19840006250