Tacrin derivater som inhibitorer af acetylcholinesterase

The invention provides compounds of formula: which have a tacrine moiety connected to an heterocyclic moiety through a linker. Through careful selection of the substituents and the linker, the activity and selectivity towards acetylcholinesterase can be modulated. The compounds show potent AChE inhi...

Full description

Saved in:
Bibliographic Details
Main Authors DEL MONTE MILLAN, MARIA, DE AUSTRIA, CELIA, USAN EGEA, PAOLA, MUNOZ RUIZ, PILAR, RUBIO ARRIETA, LAURA, GARCIA PALOMERO, ESTHER, ALONSO GORDILLO, DIANA, DORRONSORO DIAZ, ISABEL, MARTINEZ GIL, ANA, MEDINA PADILLA, MIGUEL, MORALES-ALCELAY, SUSANA, FUERTES HUERTA, ANA
Format Patent
LanguageDanish
Published 07.02.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The invention provides compounds of formula: which have a tacrine moiety connected to an heterocyclic moiety through a linker. Through careful selection of the substituents and the linker, the activity and selectivity towards acetylcholinesterase can be modulated. The compounds show potent AChE inhibition activities together with modifications in the -amyloid aggregation properties by binding simultaneously to the catalytic and peripheral AChE sites. They are useful in the treatment of AChE mediated diseases, such as the Alzheimer's disease.
Bibliography:Application Number: DK20040743319T