PYRAZOLDERIVATER MED ERGOLINSKELET ELLER SALTE DERAF, DERES FREMSTILLING, FARMACEUTISKE PRAEPARATER INDEHOLDENDE DISSE OG FREMGANGSMAADE TIL FREMSTILLING AF DE FARMACEUTISKE PRAEPARATER

The subject matter of the application are pyrazole derivatives with an ergoline skeleton of general formula wherein x...y stands for a group of formula R means a hydrogen atom or a methyl group, R1 represents a hydrogen atom or a C1-4-alkyl, carbethoxy or pyridyl group and either R2 stands for a hyd...

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Main Authors CSEH, GYORGY, RETTEGI, TIVADAR, BORSY, JOZSEF, TOLDY, LAJOS, DRUGA, ALIZ, RONAI, ANDRAS, MAGO, ERZSEBET, BERZETEI, ILONA
Format Patent
LanguageDanish
Published 09.09.1991
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The subject matter of the application are pyrazole derivatives with an ergoline skeleton of general formula wherein x...y stands for a group of formula R means a hydrogen atom or a methyl group, R1 represents a hydrogen atom or a C1-4-alkyl, carbethoxy or pyridyl group and either R2 stands for a hydrogen atom or a C1-4-alkyl, allyl, C2-4-oxoalkyl, C2-4-hydroxyalkyl or C2-4-hydroxyiminoalkyl group and R3 means a hydrogen atom or a C1-4-alkyl, hydroxy or pyridyl group or R2 and R3 together stand for a group of general formula II of claim 1, as well as their salts as well as a process for preparing them and pharmaceutical compositions containing these compounds. The above compounds above all are potent PGF2 alpha receptor antagonists.
Bibliography:Application Number: DK19840002738