ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF APOVINCAMINOL-3',4',5'-TRI-METHOXYBENZOATDERIVATER

New compounds of the general formula (I): wherein either both R and R stand for hydrogen or one of the symbols R and R is hydrogen and the other is nitro, and pharmaceutically acceptable acid addition salts thereof are prepared by reacting apovincaminol with 3,4,5-trimethoxy- benzoic acid or a react...

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Main Authors ZAJER, MARIA, KEVE, TIBOR, LORINCZ, CSABA, GYULAI, ZSUZSANNA, FORGACH, LILLA, KALAUS, GYOERGY, FEKETE, GYOERGY, ROSDY, BELA, SZABO, LAJOS, KIRALY, ARPAD, SZPORNY, LASZLO, KARPATI, EGON, SZANTAY, CSABA, ZSADON, BELA, KIRALY, GYOENGYVER, GALAMBOS, JANOS
Format Patent
LanguageDanish
Published 27.06.1988
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:New compounds of the general formula (I): wherein either both R and R stand for hydrogen or one of the symbols R and R is hydrogen and the other is nitro, and pharmaceutically acceptable acid addition salts thereof are prepared by reacting apovincaminol with 3,4,5-trimethoxy- benzoic acid or a reactive derivative thereof capable of acylation and, if desired, nitrating the resulting compound and separating the isomeric mixture of nitro derivatives thus obtained, and, if desired, converting the said compound or nitro derivatives into pharmaceutically acceptable acid addition salts thereof. These compounds can be used in therapy in the treatment of skin diseases associated with pathological cell proliferation and in the prophylaxis of such diseases.
Bibliography:Application Number: DK19820000577