Analogifremgangsmåde til fremstilling af 4-desacetoxyvincristin eller syreadditionssalte deraf

4-Deacetoxyvincristine and acid addition salts of this compound are obtained by subjecting 4-deacetoxyvinblastine to oxydative formylation and converting the resulting compound where appropriate into its acid addition salts. This compound which can be prepared according to the invention has, for exa...

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Bibliographic Details
Main Authors CSABA LORINCZ, JANOS SUGAR, JOZSEF TAMAS, ZSUZSA RELLE, KAROLA JOVANOVICS, ARON SZOLLOSY, SANDOR ECKHARDT, KALMAN SZASZ, LAJOS DANCSI
Format Patent
LanguageDanish
Published 02.02.1981
Edition3
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:4-Deacetoxyvincristine and acid addition salts of this compound are obtained by subjecting 4-deacetoxyvinblastine to oxydative formylation and converting the resulting compound where appropriate into its acid addition salts. This compound which can be prepared according to the invention has, for example, excellent cytostatic properties and is less toxic than vincristine, which has similar actions.
Bibliography:Application Number: DK19770000787