ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF ANTHELMINTISK VIRKSOMME 2-CARBALKOXYAMINO-5(6)-PHENYL-SULFONYLOXY-BENZIMIDAZOLER

Anthelmintically active 2-carbalkoxyamino-5(6)-phenylsulphonyloxy-benzimidazoles of the accompanying formula I, in which R1 denotes alkyl having 1 to 4 carbon atoms and R2 and R3 in each case independently of one another denote hydrogen, hydroxyl, alkoxy having 1 to 4 carbon atoms, halogen, trifluor...

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Bibliographic Details
Main Authors LOEWE H, DUEWEL D, KIRSCH R, URBANIETZ J
Format Patent
LanguageDanish
Published 06.10.1980
Edition3
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Anthelmintically active 2-carbalkoxyamino-5(6)-phenylsulphonyloxy-benzimidazoles of the accompanying formula I, in which R1 denotes alkyl having 1 to 4 carbon atoms and R2 and R3 in each case independently of one another denote hydrogen, hydroxyl, alkoxy having 1 to 4 carbon atoms, halogen, trifluoromethyl, alkyl having 1 to 4 carbon atoms, carbalkoxy having 1 to 4 carbon atoms in the alkoxy radical or CN are prepared by reacting an appropriate 2-carbalkoxyamino- 5(6)-hydroxybenzimidazole with an appropriately substituted benzenesulphonyl halide in the presence of a base. These compounds are distinguished by a good anthelmintic activity and are useful chemotherapeutics for the control of parasitic disorders in humans and animals, in particular those which are caused by helminths.
Bibliography:Application Number: DK19760004198