Fremgangsmåde til fremstilling af hydrohalogenider af 2,2'-anhydro-1-beta-D-arabinofuranosyl-5-fluorcytosin

Reaction of 5-fluorocytidine with the Vilsmeier-Haack reagent followed by treatment of the reaction mixture with water or a lower alkanol directly yields the previously unknown hydrohalide salts of 2,2'-anhydro-1- beta -D-arabinofuranosyl-5-fluorocytosine as crystalline solids. These compounds...

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Bibliographic Details
Main Author MAX HOFFER
Format Patent
LanguageDanish
Published 26.07.1976
Edition2
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:Reaction of 5-fluorocytidine with the Vilsmeier-Haack reagent followed by treatment of the reaction mixture with water or a lower alkanol directly yields the previously unknown hydrohalide salts of 2,2'-anhydro-1- beta -D-arabinofuranosyl-5-fluorocytosine as crystalline solids. These compounds are useful as orally or parenterally active immunorepressive or anti-neoplastic agents and as intermediates in the preparation of other acid addition salts, such as the formate of the base compound.
Bibliography:Application Number: DK19730004876