Analogifremgangsmåde til fremstilling af estere af substituerede phenyleddikesyrer eller syreadditionssalte deraf

Cpds. of general formula (I) R1=H, Me, or Et R2=H, F, Cl, or Br R3 and R4=(1-4C) alkyl, or NR3R4 forms a (4-6C) polymethyleneimino residue, or a morpholino group A=(2-3C) alkylene with at least 2C atoms between O and N. B) Salts of I C) Some cpds. III. Analgesics, antiphlogistics, and musculotropic-...

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Bibliographic Details
Main Authors ROLF DENSS, FRANZ OSTERMAYER, NIELS CLAUSON-KAAS
Format Patent
LanguageDanish
Published 12.03.1973
Edition1
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Cpds. of general formula (I) R1=H, Me, or Et R2=H, F, Cl, or Br R3 and R4=(1-4C) alkyl, or NR3R4 forms a (4-6C) polymethyleneimino residue, or a morpholino group A=(2-3C) alkylene with at least 2C atoms between O and N. B) Salts of I C) Some cpds. III. Analgesics, antiphlogistics, and musculotropic-spasmolytics. Dose 50-3000 mg. Sodium 2-(p-(1-pyrryl)phenyl)butyrate (3.0 g) and 2-piperidinoethyl chloride (2.0 g) were refluxed 15 hr. in PhMe, cooled, washed with H2O (2 x 10 ml), evapd. in vac. and distilled at 0.02 mm, bath temp. 240-250 deg. The distillate in Et2O was treated with 2.8N HCl/Et2O (4 ml), giving I HCl, m.p 114-7 deg. (from butanone).
Bibliography:Application Number: DK19690002196