Fremgangsmåde til fremstilling af quetiapin og mellemprodukter dertil

The invention refers to a novel process for the preparation of 11-[4-/2-(2-hydroxyethoxy)ethyl/-1-piperazinyl]dibenzo[b,f]-1,4-thiazepine of the formula (I) known as quetiapine. According to the invention, a haloethylpiperazinylthiazepine derivative of the formula (VIII), wherein Hal stands for a ha...

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Main Authors TOEMPE, PETER, SIMIG, GYULA, BOZSING, DANIEL, RAKOCZY, GYOERGYNE, NAGY, KALMAN, KRASZNAI, GYOERGY, KOVANYINE LAX, GYOERGYI, VERECZKEYNE DONATH, GYOERGYI
Format Patent
LanguageDanish
Published 12.07.2004
Edition7
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Summary:The invention refers to a novel process for the preparation of 11-[4-/2-(2-hydroxyethoxy)ethyl/-1-piperazinyl]dibenzo[b,f]-1,4-thiazepine of the formula (I) known as quetiapine. According to the invention, a haloethylpiperazinylthiazepine derivative of the formula (VIII), wherein Hal stands for a halo atom, is reacted with ethylene glycol.
Bibliography:Application Number: DK20010904235T