Fremgangsmåde til fremstilling af additionsforbindelser af tetracyclin, oxytetracyclin eller chlortetracyclin

An addition compound of a tetracycline antibiotic, streptomycin or neomycin, or a salt thereof, is formed by reacting the antibiotic with a compound of general Formula I <FORM:1042836/C2/1> where R is C8- 18 alkyl and X is halogen. The preferred compound I is dodecylacetate pyridinium chloride...

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Bibliographic Details
Main Authors LAJOS STANKOVICS, FERENC VARGA, EVA SZENTIRMAI, LASZLO TARDOS.MED, GYOERGY DOBIAS.MED, ILONA ERDELYI, GYOERGY SZECSEY.MED
Format Patent
LanguageDanish
Published 01.06.1970
Edition1
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
DERIVATIVES THEREOF
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SPIRITS
SUGARS
VINEGAR
WINE
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Summary:An addition compound of a tetracycline antibiotic, streptomycin or neomycin, or a salt thereof, is formed by reacting the antibiotic with a compound of general Formula I <FORM:1042836/C2/1> where R is C8- 18 alkyl and X is halogen. The preferred compound I is dodecylacetate pyridinium chloride. The tetracycline antibiotic may be tetracycline, chlortetracycline or oxytetracycline. The addition compounds are therapeutically active. Tetracyclines, streptomycin and neomycin may be isolated from aqueous solutions thereof by adding a compound of Formula I to the aqueous solution of the antibiotic, adjusting to pH 7 to 8 to precipitate the above addition compound and recovering the antibiotic from the addition compound, e.g. by treatment with a mineral acid. Dodecylacetate pyridinium chloride is prepared by reacting monochloracetic acid dodecyl ester with pyridine.ALSO:Pharmaceutical compositions for oral, rectal or parenteral use in the treatment of humans and animals comprises a carrier and at least one addition compound of a tetracycline antibiotic, streptomycin, neomycin or a salt thereof with a compound of general formula I <FORM:1042836/A5-A6/1> where R is C8-18 alkyl and X is a halogen atom. Preferred is the addition compound with dodecylacetate pyridinium chloride. Optional additions are vitamins. For veterinary use, the impure addition compound obtained from a fermentation mash may be used with a carrier e.g. calcium carbonate.
Bibliography:Application Number: DK19640000599