Ny krystalmodifikation N af torasemid

New crystalline polymorph of torasemide, characterized by its powder x-ray diffraction pattern data; and its preparation by controlled acidification of alkaline torasemide solutions at specific temperatures and over specific periods. New crystal modification (form III) of torasemide, with spacings (...

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Main Authors FISTRIC, INES, DANILOVSKI, ALEKSANDAR, DUMIC, MILJENKO, HORVAT MIKULCIC, JASNA, ORESIC, MARINA, FILIC, DARKO, KLEPIC, BOZENA
Format Patent
LanguageDanish
Published 29.03.2005
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:New crystalline polymorph of torasemide, characterized by its powder x-ray diffraction pattern data; and its preparation by controlled acidification of alkaline torasemide solutions at specific temperatures and over specific periods. New crystal modification (form III) of torasemide, with spacings (d) between lattice planes, expressed in angstroms as 15.3898, 12.5973, 11.4565, 9.7973, 9.5493, 8.6802, 8.2371, 7.6351, 7.3356, 6.9759, 6.5351, 6.3240, 6.1985, 5.9521, 5.6237, 5.5623, 5.4040, 5.1119, 4.8738, 4.7865, 4.6986, 4.5985, 4.4602, 4.3405, 4.2552, 4.1829, 4.0768, 3.9377, 3.8659, 3.8429, 3.7801, 3.7248, 3.6239, 3.5556, 3.4825, 3.4130, 3.3055, 3.2298, 3.1786, 3.1278, 3.0699, 3.0078, 2.9549, 2.9056, 2.8541, 2.7686, 2.6988, 2.6610, 2.6293, 2.5549, 2.5236, 2.4485, 2.4161, 2.3671, 2.3133, 2.2788, 2.2312, 2.1852, 2.1468, 2.0957, 2.0617, 2.0273, 1.9896, 1.9688, 1.9274, 1.8853, 1.7931, 1.7449, 1.7169, 1.6512, 1.6122, 1.5601, 1.5320, 1.5057, 1.4521, and 1.3773. An independent claim is also included for the preparation of this new modification form III, by controlled acidification of an alkaline torasemide solution with inorganic or organic acids, with or without addition of a seed crystal, at a temperature of 0-35[deg]C within a period of 0.25-25 hours. ACTIVITY : Diuretic; cardiovascular; hypotensive; cardiant; ophthalmological; cytostatic; anticonvulsant; antiallergic; antiasthmatic. MECHANISM OF ACTION : None given.
Bibliography:Application Number: DK19990949272T