Nye 3,4-diarylthiophener og analoge deraf til anvendelse som antiinflammatoriske midler

A class of 3,4-diaryl substituted furan derivatives and analogs thereof, and pharmaceutical compositions containing them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defined by a formula selected from wherein X is hydrogen or hydroxy; wherein R2 is a...

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Main Authors ROGERS, ROLAND, S, PAUL, W. COLLINS, STEPHEN, R. BERTENSHAW, ROLAND, S. ROGERS, BERTENSHAW, STEPHEN, R, PENNING, THOMAS, D, DAVID, B. REITZ, THOMAS, D. PENNING, REITZ, DAVID, B, COLLINS, PAUL, W
Format Patent
LanguageDanish
Published 27.07.1998
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A class of 3,4-diaryl substituted furan derivatives and analogs thereof, and pharmaceutical compositions containing them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defined by a formula selected from wherein X is hydrogen or hydroxy; wherein R2 is aryl optionally substituted with a radical selected from halo, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, nitro, amino, sulfamyl and lower alkylsulfonylamino; and wherein R3 is aryl optionally substituted with a radical selected from halo, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, nitro, amino, lower alkylamino, lower alkylsulfonylamino and sulfamyl; provided that at least one of R2 and R3 is substituted with methylsulfonyl or sulfamyl; or a pharmaceutically-acceptable salt thereof.
Bibliography:Application Number: DK19940906625T