Rapamycin-arylcarbonyl- og alkoxycarbonyl-carbamater som immunsuppressive og antifungiske midler

N-arylcarbonyl and N-alkylcarbonyl carbamates of rapamycin of the formula shown below wherein R1 and R2 are both and where A is lower alkoxy or aryl or heteroaryl, R3 is H or methyl and R4 is C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl possess immunosuppressive and/or antifungal and/or antitumor and...

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Bibliographic Details
Main Author KAO, WENLING
Format Patent
LanguageDanish
Published 09.11.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:N-arylcarbonyl and N-alkylcarbonyl carbamates of rapamycin of the formula shown below wherein R1 and R2 are both and where A is lower alkoxy or aryl or heteroaryl, R3 is H or methyl and R4 is C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl possess immunosuppressive and/or antifungal and/or antitumor and/or antiinflammatory activity in vitro and/or inhibit thymocyte proliferation in vivo. These compounds are thus expected to be useful in the treatment of transplantation rejection, autoimmune diseases, fungal infections, cancer, and diseases of inflammation.
Bibliography:Application Number: DK19930923284T