Højrene krystallinske former af peptider Arg-Lys-Asp og Arg-Lys-Asp-Val, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdende dem

The present invention relates to a process for the preparation of high purity crystalline forms of peptides Arg-Lys-Asp and Arg-Lys-Asp-Val from crude, amorphous peptides Arg-Lys-Asp and Arg-Lys-Asp-Val. The process is characterized in that the crude, amorphous peptide Arg-Lys-Asp or peptide Arg-Lys...

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Main Authors HAJOS, GY, UBERHARDT, ILDIKO, NYEKI, OLGA, SCHON, ISTVAN DR, MUCK, ZSUZSANNA, UBERHARDT, TAMAS, PETER, IMRE, GAZDAG, MARIA DR, KOVACS, LAJOS, SZPORNY, LASZLO, LORANT, GIZELLA, DENES, LASZLO,DR, IVANYI, GEZA
Format Patent
LanguageDanish
Published 06.05.1996
Edition5
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a process for the preparation of high purity crystalline forms of peptides Arg-Lys-Asp and Arg-Lys-Asp-Val from crude, amorphous peptides Arg-Lys-Asp and Arg-Lys-Asp-Val. The process is characterized in that the crude, amorphous peptide Arg-Lys-Asp or peptide Arg-Lys-Asp-Val is allowed to stand at room temperature with 5 to 20 unit volume of an ethanolic solution containing 0.5 to 4.0% by volume of acetic acid and 5 to 25% by volume of water, wherein the volume unit is calculated for the mass unit of the material and mass unit relates to volume unit as g relates to ml, then the crystallized peptide is separated from the crystalline suspension, preferably after cooling. Pharmaceutical compositions containing the crystalline forms of these peptides are also described.
Bibliography:Application Number: DK19910307788T