KONDENSIERTE PYRIDAZINONVERBINDUNGEN

• Main Authors: ANGYAL, AGNES, VARGA, ILDIKO, ANDRASI, FERENC, MATYUS, PETER, SZABO, ERZSEBET, TARNAWA, ISTVAN, SZABO, KATALIN, SIMAY, ANTAL, HARSING, LASZLO, MORAVCSIK, IMRE, PAPP, AGNES, BERZSENYI, PAL, BOROS, SANDOR, HORVATH, KATALIN
• Format: Patent
• Language: German
• Published: 16.10.2003
• Edition: 7

Novel pyridazino[4,5-b][1,5]oxazepinone, thiazepinone and diazepinone derivatives of general formula (I) wherein: R stands for hydrogen atom or a group of formula NHR , wherein: R stands for hydrogen, C1-4 alkyl or C2-5 acyl group, R stands for C1-4 alkyl or C2-4 alkenyl group, which may be substituted by a phenyl group, or phenyl group, W stands for methylene or carbonyl group, X and Y stand independently for oxygen or sulphur atom, SO, SO2 or NR group, wherein R is hydrogen atom, C1-4 alkyl group or a group of formula (II), wherein R stands for hydrogen or halogen atom, C1-4 alkoxy or nitro group or a group of formula NHR , wherein R has the above meaning, and Z stands for methylene or carbonyl group, further n has a value of 0, 1 or 2, with the proviso that when any of X or Y stands for oxygen or sulphur atom, SO or SO2 group or a group of formula NR , wherein R stands for hydrogen atom or C1-4 alkyl group, then the other may stand only for an NR group, wherein R stands for a group of formula (II) - wherein R , Z and n have the above meanings - and their tautomers and the acid-addition salts of all these compounds. The compounds according to the invention show memory-enhancing and neuroprotective properties.