VERWENDUNG VON BREFELDIN A UND DEREN DERIVATE IN DER HERSTELLUNG VON ARZNEIMITTEL ZUR BEHANDLUNG VON HYPERPLASIE UND VERWANDTEN ERKRANKUNGEN
Methods for inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise administering to the mammal an effective amount of Brefeldin A or a derivative of Brefeldin A. The methods are useful in reducing intimal hyperplasia due to, for example,...
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Main Authors | , , , |
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Format | Patent |
Language | German |
Published |
27.07.2006
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Subjects | |
Online Access | Get full text |
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Summary: | Methods for inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise administering to the mammal an effective amount of Brefeldin A or a derivative of Brefeldin A. The methods are useful in reducing intimal hyperplasia due to, for example, vascular injuries resulting from angioplasty, endarterectomy, reduction atherectomy or anastomosis of a vascular graft. The non-peptide PDGF antagonists Brefeldin A and its derivatives may optionally be administered coordinately with heparin, whereby the coordinately administered of non-peptide PDGF antagonist and heparin are combinatorially effective in inhibiting intimal hyperplasia. |
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Bibliography: | Application Number: DE19966035614T |