NEUES AMIDINONAPHTHYLDERIVAT ODER DESSEN SALZ

• Main Authors: KOSHIO, HIROYUKI, YANAGISAWA, ISAO, KAWASAKI, TOMIHISA, MATSUMOTO, YUZO, KAKU, SEIJI, HIRAYAMA, FUKUSHI
• Format: Patent
• Language: German
• Published: 24.12.2003
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

An amidinonaphthyl derivative represented by the following general formula (I) which has a platelet aggregation inhibiting action based on the activated blood coagulation factor X inhibiting action and is useful as an anti-thrombus agent and the like, a salt thereof, an intermediate thereof and a pharmaceutical composition which comprises the amidinonaphthyl derivative. An amidinonaphthyl derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof. (symbols in the formula have the following meanings; R : a hydrogen atom or a group represented by the formula -A-W-R , A: a group represented by the formula a group represented by the formula or a group represented by the formula -SO2-, X: an oxygen atom or a sulfur atom, W: a single bond or a group represented by the formula -NR -, R : a hydroxyl group, a lower alkoxy group, etc., not a hydroxyl group or a lower alkoxy group, R : a hydrogen atom, a carbamoyl group, a lower alkoxycarbonyl group, etc., R : a lower alkyl group, R : a hydrogen atom, a halogen atom, a carboxyl group, B: a lower alkylene group or a carbonyl group, and n: 0 or 1).