PYRIDYL-IMIDAZOL-DERIVATE UND VERFAHREN ZU IHRER HERSTELLUNG

• Main Authors: SHIN, AH, YOO, EUN, CHA, OK JA, LEE, HOU, KIM, JU, YI, YANG, KIM, RYUNG, JUNG, SOOK, SEO, WON, KIM, JEONG, SHIN, WHA SUP, LEE, SUK, LEE, HEE, SUH, HEE, LEE, HO
• Format: Patent
• Language: German
• Published: 28.12.2000
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PCT No. PCT/KR95/00075 Sec. 371 Date Dec. 6, 1996 Sec. 102(e) Date Dec. 6, 1996 PCT Filed Jun. 7, 1995 PCT Pub. No. WO95/34564 PCT Pub. Date Dec. 21, 1995Novel pyridyl imidazole derivatives of formula(I) inhibit effectively the action of angiotensin II and have a superior antihypertensive activity: d or cyclic C1-C6 alkyl or alkenyl group, OR1 (wherein R1 is a hydrogen, or a straight, branched or cyclic C1-C6 alkyl or alkenyl radical), or NR2R3 (wherein R2 and R3 are independently a hydrogen, or a straight, branched or cyclic C1-C6 alkyl radical); B is a group of the following formula D is a hydrogen; a halogen; a straight, branched or cyclic C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl group which is optionally substituted with OH, a C1-C4 alkoxy radical, CO2R1, COR1, CON(R1)2 or N(R1)2, wherein R1 is the same as defined above; tetrazol-5-yl; a perfluoro-C1-C4 alkyl group; or N(R1)2, OR1, CO2R1 or CON(R1)2, wherein R1 is the same as defined above; E is a hydrogen; a halogen; a straight or branched C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl group which is optionally substituted with OH, a C1-C4 alkoxy radical, CO2R1, COR1, CON(R1)2 or N(R1)2, wherein R1 is the same as defined above; a perfluoro-C1-C4 alkyl group; NO2; or N(R1)2 or OR1, wherein R1 is the same as defined above; and n is 0 or an integer of 1 to 4.