VERFAHREN ZUR ISOLATION VON LOVASTATIN

PCT No. PCT/SI94/00010 Sec. 371 Date Jun. 17, 1996 Sec. 102(e) Date Jun. 17, 1996 PCT Filed Jun. 8, 1994 PCT Pub. No. WO94/29292 PCT Pub. Date Dec. 22, 1994There is disclosed a process for the isolation of the hypolipaemic active substance lovastatin from a sample, e.g. fermentation broth, mycelium...

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Main Authors POKORNY, MIROSLAV, 68000 NOVO MESTO, SI, VESEL, TANJA, 68000 NOVO MESTO, SI, HAJKO, PAVICA, 68000 NOVO MESTO, SI, RADEZ, IVAN, 68000 NOVO MESTO, SI
Format Patent
LanguageGerman
Published 19.11.1998
Edition6
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:PCT No. PCT/SI94/00010 Sec. 371 Date Jun. 17, 1996 Sec. 102(e) Date Jun. 17, 1996 PCT Filed Jun. 8, 1994 PCT Pub. No. WO94/29292 PCT Pub. Date Dec. 22, 1994There is disclosed a process for the isolation of the hypolipaemic active substance lovastatin from a sample, e.g. fermentation broth, mycelium or filtrate of Aspergillus terreus (ATCC 20542) or Aspergillus oryzae (ATCC 74135) by extraction with butyl acetate. Simultaneously with the concentration of the extract, lactonisation takes place. There follows a direct crystallization of lovastatin in the lactone form from butyl acetate.
Bibliography:Application Number: DE19946009516T