Verfahren zur Herstellung von 2',3'-didehydro-2'3'-didesoxynukleosiden im Grossmassstab

An improved process suitable for large-scale production of 2',3'-didehydro-3'-deoxythymidine (d4T) and close analogs is disclosed. The improved process yields d4T in high yield and purity without the use of hazardous reactions or reagents and incorporates several process improvements...

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Bibliographic Details
Main Authors BOYHAN, BRENDA T., EDISON, NY 08817, US, BAKER, STEPHEN R., CICERO, NY 13039, US, SKONEZNY, PAUL M., CICERO, NY 13039, US, STARK, DERRON R., SYRACUSE, NY 13203, US, EISENREICH, EMERICH, E. SYRACUSE, NY 13057, US
Format Patent
LanguageGerman
Published 11.09.1997
Edition6
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:An improved process suitable for large-scale production of 2',3'-didehydro-3'-deoxythymidine (d4T) and close analogs is disclosed. The improved process yields d4T in high yield and purity without the use of hazardous reactions or reagents and incorporates several process improvements important on a large scale including a novel purification step involving the isolation of a d4T.N-methylpyrrolidinone solvate.
Bibliography:Application Number: DE19946001698T