MULTIVALENTE UND MULTISPEZIFISCHE BINDUNGSPROTEINE, DEREN HERSTELLUNG UND VERWENDUNG

PCT No. PCT/GB93/02492 Sec. 371 Date May 14, 1996 Sec. 102(e) Date May 14, 1996 PCT Filed Dec. 3, 1993 PCT Pub. No. WO94/13804 PCT Pub. Date Jun. 23, 1994Polypeptides comprising a first domain, which comprises a binding region of an immunoglobulin heavy chain variable region, and a second domain, wh...

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Main Authors POPE, ANTHONY RICHARD, PROSPERO, TERENCE DEREK, HOLLIGER, KASPAR-PHILIPP, HOOGENBOOM, HENDRICUS RENERUS JACOBUS MATHEUS, GRIFFITHS, ANDREW DAVID, WINTER, GREGORY PAUL, MALMQVIST, MAGNUS, MCGUINNESS, BRIAN TIMOTHY, MARKS, JAMES DAVID
Format Patent
LanguageGerman
Published 19.07.2001
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMBINATORIAL CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:PCT No. PCT/GB93/02492 Sec. 371 Date May 14, 1996 Sec. 102(e) Date May 14, 1996 PCT Filed Dec. 3, 1993 PCT Pub. No. WO94/13804 PCT Pub. Date Jun. 23, 1994Polypeptides comprising a first domain, which comprises a binding region of an immunoglobulin heavy chain variable region, and a second domain, which comprises a binding region of an immunoglobulin light chain variable region, the domains being linked but incapable of associating with each other to form an antigen binding site, associate to form antigen binding multimers, such as dimers, which may be multivalent or have multispecificity. The domains may be linked by a short peptide linker or may be joined directly together. Bispecific dimers may have longer linkers. Methods of preparation of the polypeptides and multimers and diverse repertoires thereof, and their display on the surface of bacteriophage for easy selection of binders of interest, are disclosed, along with many utilities.
Bibliography:Application Number: DE19936029974T