Ein Verfahren zur Herstellung von Finasteride

Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17β-carboalkoxy-4-aza-5α-androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the ester, formed from t-butyl amine and an aliphatic/aryl magnesium hali...

Full description

Saved in:
Bibliographic Details
Main Authors DOLLING, ULF H., WESTFIELD, NJ 07090, US, VARSOLONA, RICHARD J., SCOTCH PLAINGS, NJ 07076, US, MCCAULEY, JAMES A., BELLE MEAD, NJ 08502, US
Format Patent
LanguageGerman
Published 05.11.1998
Edition6
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
ELECTRIC COMMUNICATION TECHNIQUE
ELECTRICITY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PICTORIAL COMMUNICATION, e.g. TELEVISION
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
STEROIDS
Online AccessGet full text

Cover

More Information
Summary:Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17β-carboalkoxy-4-aza-5α-androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the ester, formed from t-butyl amine and an aliphatic/aryl magnesium halide at ambient temperature in an inert organic solvent under an inert atmosphere followed by heating and recovering the product finasteride.Also disclosed are two polymorphic crystalline Forms I and II of finasteride, and methods of their production.
Bibliography:Application Number: DE19936017856T