Neue 15-nitro-2-beta, 3 Beta-dihydro und 15-Nitro-2-beta, 3-Beta,6,7-Tetrahydrotabersoninederivate, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung

• Main Authors: SZOMBATHELYI, ZSOLT, H-1134 BUDAPEST, HU, SARKADI, ADAM, H-1146 BUDAPEST, HU, BARTA, MARGIT, H-1082 BUDAPEST, HU, BOLYA, VIKTORIA, H-1103 BUDAPEST, HU, GERE, ANIKO, H-1111 BUDAPEST, HU, KISS, BELA, H-1103 BUDAPEST, HU, ZSADON, BELA, H-1113 BUDAPEST, HU, KARPATI, EGON, H-1022 BUDAPEST, HU, CSOMOR, KATALIN, H-1045 BUDAPEST, HU, LASZY, JUDIT, H-2094 BUDAPEST, HU, LAPIS, ERZSEBET, H-1173 BUDAPEST, HU, SZILASI, MARIA, H-1113 BUDAPEST, HU, KEVE, TIBOR, H-1121 BUDAPEST, HU, GALAMBOS, JANOS, H-1162 BUDAPEST, HU, REPASI, EMILIA, H-1103 BUDAPEST, HU, BODO, MIHALY, H-1026 BUDAPEST, HU, SZPORNY, LASZLO, H-1114 BUDAPEST, HU, PALOSI, EVA, H-1025 BUDAPEST, HU, SZABO, SANDOR, H-1061 BUDAPEST, HU, SZENTIRMAY, ZSOLT, H-1158 BUDAPEST, HU
• Format: Patent
• Language: German
• Published: 29.08.1996
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to novel 15-nitro-2 beta ,3 beta -dihydro- and 15-nitro-2 beta ,3 beta ,6,7-tetrahydrotabersonine derivatives of the formula (I), wherein R stands for hydrogen; R stands for hydrogen or a C1-6alkyl group; and the symbol @ @ represents a single or double bond as well as their salts. The invention further relates to pharmaceutical compositions containing the above compounds as well as a process for the preparation of the above compounds of formula (I) and of the pharmaceutical compositions. The compounds of formula (I) exert a reducing or inhibitory effect on cerebral edema and show antihypoxic properties. Thus, they are useful for the prevention or treatment of brain injuries of various origin induced by hypoxia of the brain.