PHOSPHORYLIERTE PRODRUGS

The composition and methods of synthesis of several prodrugs are described. These methods may be used to convert negatively charged phosphorous bearing drugs into neutrally charged; lipid soluble prodrugs which are able to passively diffuse into cells and through biological membranes. Prodrugs for a...

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Bibliographic Details
Main Author GLAZIER, ARNOLD, NEWTON, MASS., US
Format Patent
LanguageGerman
Published 17.10.1996
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:The composition and methods of synthesis of several prodrugs are described. These methods may be used to convert negatively charged phosphorous bearing drugs into neutrally charged; lipid soluble prodrugs which are able to passively diffuse into cells and through biological membranes. Prodrugs for a variety of antiviral and anti-leukemic agents are described. A class of prodrugs which undergo degradation by an elimination reaction to form a carbon-carbon double bond is described. This elimination reaction is triggered by esterase.
Bibliography:Application Number: DE19916015694T