Wasserlösliche Derivate der Bioflavonoidglykoside, Verfahren zu ihrer Herstellung und pharmazeutische Präparate davon

The derivatives of glycoside bioflavonoids having general formula: wherein P represents the flavonic residue containing phenolic hydroxyls and R min represents H, (CO-R-CO-O-N)n , in which X is selected among H, the cation of a pharmaceutically acceptable base and the radicals of polyoxyethylenglyco...

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Main Authors GHEDINI, NADIA, I-40133 BOLOGNA, IT, TUMIATTI, VINCENZO, I-37020 CERRO VERONESE (VR), IT, ANDRISANO, VINCENZA, I-40139 BOLOGNA, IT, SCAPINI, GIANCARLO, I-40123 BOLOGNA, IT
Format Patent
LanguageGerman
Published 23.10.1997
Edition6
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:The derivatives of glycoside bioflavonoids having general formula: wherein P represents the flavonic residue containing phenolic hydroxyls and R min represents H, (CO-R-CO-O-N)n , in which X is selected among H, the cation of a pharmaceutically acceptable base and the radicals of polyoxyethylenglycols, polyoxypropylenglycols and their monomethylethers and R is an alkyl or aryl radical of a dicarboxylic acid, are water soluble and biodecomposable, maintaining at least the same therapeutical activity of the starting bioflavonoids. For their preparation the starting glycoside is reacted with the anhydride of the dicarboxylic acid , the resulting ether carboxylic derivative is reacted with a pharmaceutically acceptable base, for instance an alkali methal hydroxyde, carbonate or bicarbonate, or with polyoxyethylenglycol, polyoxypropylenglycol or their monomethylethers.
Bibliography:Application Number: DE19906030292T