FÜr DIE CO4-BINDENDE DOMÄNE VON HIV SPEZIFISCHE ANTIKÖRPER

A particular epitope located within the CD4-binding region of gp120 of HIV-1, and antibody specific for the epitope which can inhibit diverse strains and isolates of the virus, is disclosed. The antibody can be used in immunotherapy of HIV-1 infection. In addition, neutralizing antibody against this...

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Main Authors SUN, CECILY, ROU-YUN, HOUSTON, TX 77005, US, SUN, WILLIAM, NAIAU, BELLAIRE, TEXAS 77401, US, FUNG, MICHAEL, SEK, C., HOUSTON, TX 77025, US, CHANG, TSE-WEN, HOUSTON, TX 77008, US, CHANG, NANCY, T., HOUSTON, TX 77005, US
Format Patent
LanguageGerman
Published 28.05.1997
Edition6
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:A particular epitope located within the CD4-binding region of gp120 of HIV-1, and antibody specific for the epitope which can inhibit diverse strains and isolates of the virus, is disclosed. The antibody can be used in immunotherapy of HIV-1 infection. In addition, neutralizing antibody against this conserved epitope can be used in immunoconjugates to target virally-infected cells.
Bibliography:Application Number: DE19906029937T