VERFAHREN ZUR HERSTELLUNG VON 1-(2S,3S)-2-BENZHYDRIL-N-(5-TERT.-BUTYL-2-METHOXYBENZYL)CHINUKLIDIN-3-AMIN

This invention relates to an improved process for the preparation of (2S,3S)-2-benzhydryl-N-(5-tent-butyl-2-methoxybenzyl)quinuclidin-3-amine, (hereinafter "compound of Formula I") and its pharmaceutically acceptable salts. In particular, the invention is directed to an improved synthesis...

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Bibliographic Details
Main Authors POST, RONALD JAMES, SMITH, JULIAN DUNCAN, BASFORD, PATRICIA ANN, TABER, GERALDINE PATRICIA
Format Patent
LanguageGerman
Published 29.05.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:This invention relates to an improved process for the preparation of (2S,3S)-2-benzhydryl-N-(5-tent-butyl-2-methoxybenzyl)quinuclidin-3-amine, (hereinafter "compound of Formula I") and its pharmaceutically acceptable salts. In particular, the invention is directed to an improved synthesis of the monohydrate citrate salt of the compound of Formula (Ia).
Bibliography:Application Number: DE20056003791T